![]() ![]() KFD is a rare nonmalignant disorder that affects the lymph nodes. However, in some people, it can be associated with autoimmune disorders, conditions where the immune system mistakenly attacks the body’s cells and tissues. Usually, this disease does not cause severe problems and gets better on its own. This unusual pattern makes it distinct from other diseases with similar symptoms. In simpler terms, KFD is a unique condition where the affected tissue shows signs of cell death, but the immune cells generally associated with that kind of reaction are missing. Instead, the necrotic areas mainly contain remnants of cells undergoing apoptosis, where the cell nucleus breaks down. When the lymph nodes are examined under a microscope, specific changes may be seen such as tissue necrosis (cell death) and an absence of a particular type of immune cell called neutrophils. KFD is similar to a type of inflammatory response called granulomatous response. KFD shows up as painful swelling of lymph nodes, often in the neck, along with general symptoms like fever and fatigue. This disorder presents with similar signs and symptoms as lymphoma, including enlarged lymph nodes (lymphadenopathy) The exact cause is not known. While slightly more common in females, it is also seen in males. Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenopathy, is a rare, benign (noncancerous, nonmalignant) disorder of the lymph nodes, predominantly of young adults and school aged children. Stay Informed With NORD’s Email Newsletter.Find a Rare Disease Patient Organization.Rare Disease Cures Accelerator (RDCA-DAP).Find Clinical Trials & Research Studies. ![]()
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